While the last line always feels unfortunately despondent, it reinforces the deflated sense of self-importance that the rest of the essay tries to instill in the reader. Worry not about what others think of you, because they don’t think much at all.
The most useful medicines are often unpleasing to the taste. Those who are oppressed by their own reputation, will, perhaps, not be comforted by hearing that their cares are unnecessary. But the truth is, that no man is much regarded by the rest of the world. He that considers how little he dwells upon the condition of others, will learn how little the attention of others is attracted by himself. While we see multitudes passing before us, of whom, perhaps, not one appears to deserve our notice, or excite our sympathy, we should remember, that we likewise are lost in the same throng; that the eye which happens to glance upon us is turned in a moment on him that follows us, and that the utmost which we can reasonably hope or fear is, to fill a vacant hour with prattle, and be forgotten.